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Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by selectively inhibiting the enzyme COX-2, which plays a key role in the production of prostaglandins that cause inflammation and pain. Celecoxib is preferred over some other NSAIDs due to … Find drug information for Celebrex on CVS.com, including related drug classes, side effects, dosage, and answers to frequently asked questions. 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