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If so, is there a cost difference with that form and the prescription form of the drug? No, promethazine is not available over the counter. The drug is only available if a doctor prescribes it. The cost of promethazine could vary depending on which dosage form your doctor prescribes. Compare Phenergan prices, print discount coupons, find manufacturer promotions, copay cards and patient assistance programs. Promethazine with codeine treats cold, flu, allergies, or breathing illness symptoms. Learn about this medication and its usage at Blink Health. Promethazine Medications Promethazine is a medication that belongs to the class of drugs known as antihistamines. More specifically, it's an older, first-generation antihistamine (brand name example: Phenergan) that has multiple uses beyond just allergy relief. 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Learn if it's addictive, where to buy it, and if it's available over the counter in the UK. You can buy the medication under either its brand name or its generic name. What to use instead of Phenergan? The best alternative depends on the reason for use: For Sleep: Other over-the-counter options include antihistamines like diphenhydramine (Nytol). Herbal remedies like valerian may also be considered. For persistent insomnia, consult a … While prescription medications like Phenergan are effective in alleviating these symptoms, many people prefer the convenience and accessibility of over-the-counter (OTC) options. Buy Phenergan 25mg (Promethazine Hydrochloride) Phenergan 25mg (Promethazine Hydrochloride) tablets are designed to treat a range of conditions, including allergic reactions like hay fever and rashes, travel sickness and insomnia. 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