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Some people have an allergy to the ingredients in levothyroxine, while others find that T4-only medications can't relieve hypothyroid symptoms. Fortunately, there are numerous over-the-counter alternatives for levothyroxine. Concerned about affording your Synthroid medication? RxSaver can help you save on prescription costs. 3. Are there any over-the-counter (OTC) alternatives to Levothyroxine available in Canada? Answer: OTC alternatives to Levothyroxine are limited in Canada. Consulting a healthcare provider for prescription-based treatment options is typically recommended. 4. How often should I have my thyroid function monitored while on Levothyroxine? Sign up for free home deliveries of Synthroid and access to on-call pharmacy support. Synthroid is a prescription drug and can not be bought over the counter. Talk to your healthcare provider to determine if the drug is right for you. What is Synthroid used for? 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