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Disulfiram generic, often prescribed through the Antabuse prescription medication, is issued to help battle alcoholism. Learn how the drug interferes with the body's processing of alcohol, how to use it, and things to consider before taking Antabuse. Disulfiram is an oral prescription drug used for treating alcoholism. Antabuse is used of treating alcoholism in combination with supportive care and psychotherapy. Alcohol is converted in the body into acetaldehyde by an enzyme called alcohol dehydrogenase. Another enzyme called acetaldehyde dehydrogenase then converts acetaldehyde into acetic acid. Disulfiram prevents acetaldehyde … Medscape – Indication-specific dosing for Antabuse (disulfiram), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Antabuse (disulfiram) is a medication that acts as a deterrent treatment for alcohol use disorder. 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